Now a days sartan
family of medicine are on tip of the tongue of pharmaceutical professionals in
the view of potential nitrosamine impurities issues and challenges to control
it.
Here, we will have a
brief overview on the -Sartan family of medicine. To get the
answers of very common questions about the Sartans i.e. what are
sartans? For what it is being used?
What are sartan drugs
and usage?
-Sartan is the suffix given to the drugs which belongs to a class of medicine known as Angiotensin II receptor blockers (ARBs). Like; Valsartan,
losartan, Irbesartan, Candesartan, Azilsartan etc.
Name of class speaks,
these medicines (-sartans) have a mode of action to block the receptors of
Angiotensin II
Angiotensin II is a
type of peptide/protein hormone, which leads to narrow the blood vessels to
control the blood pressure as well as fluid balance in the body. Hence, these
are being used to treat high blood pressure and heart failure.
Origin of
angiotensin-II is from protein named angiotensinogen, being secrets by liver.
Which further undergoes enzymatic reaction (renin: produced in kidney) and
forms angiotensin-I. This angiotensin-I further metabolized and get converted
in angiotensin-II, when it enters in bloodstream.
has an effect to increase the blood pressure, body fluid and sodium content. Hence, -sartans are being used to treat high blood pressure and heart failure.
In recent years Nitrosamine
impurities has become a very hot topic among the pharmaceutical professionals
and researchers. Various pharmaceutical regulators are also in action to get
overcome and deal with such problem related to health of human beings.
In upcoming article
we will see what is this Issue of Nitrosamine impurities in -sartans.
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